Hpv Infection and Related Oral Diseases
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چکیده
Definition Human Papillomaviruses (HPVs) are a group of DNA viruses, which have a remarkable target cell specificity: they have been reported principally in anogenital tract, urethra, skin, larynx, tracheobronchial mucosa and oral cavity. More than 100 different types of HPV have been classified and they are divided into high (e.g. 16,18, 31) and low oncogenic risk genotypes (e.g. 11, 42, 36), depending on the association with malignant change. The viral products stimulate cell growth in the basal layer leading to formation of a common wart. Since the recognition of high risk HPVs in oral carcinomas, the malignant potential of HPV infection has been suggested. A recent metanalysis, including 94 studies about HPV presence in oral mucosa (range 0-100%) showed that oral dysplasia and oral squamous carcinoma are more commonly associated with HPV infection (type 16 and 18) compared with normal oral mucosa.
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Controversies surrounding human papilloma virus infection, head & neck vs oral cancer, implications for prophylaxis and treatment
Head & Neck Cancer (HNC) represents the sixth most common malignancy worldwide and it is historically linked to well-known behavioural risk factors, i.e., tobacco smoking and/or the alcohol consumption. Recently, substantial evidence has been mounting that Human Papillomavirus (HPV) infection is playing an increasing important role in oral cancer. Because of the attention and clamor surrounding...
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Oral human papillomavirus (HPV) infection is the cause of 40% to 80% of oropharyngeal cancers; yet, no published study has examined the role of oral health in oral HPV infection, either independently or in conjunction with other risk factors. This study examined the relation between oral health and oral HPV infection and the interactive effects of oral health, smoking, and oral sex on oral HPV ...
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